This is a specific tool that searches for GPCR sequences in proteomes.

Cribrum classifies the putative GPCR sequences in probable family or subfamilies at different tree-depth, according to the level of knowledge and availability of the different GPCR subfamily members. These are derived from a newly consistent annotation of the loops and transmembrane segments for the G-Protein Coupled Receptor proteins found in public (or custom) databases and reclassified according to a BioDec procedure.